Fisetin Vs Quercetin in Benefits and Effectiveness

Fisetin Vs Quercetin

As we age, our bodies undergo various changes, including a decline in cognitive function, increased inflammation, and an increased risk of multiple diseases. However, research suggests that certain compounds, such as fisetin and quercetin, may offer anti-aging and other health benefits.

Fisetin and quercetin are flavonoids, naturally occurring compounds in various fruits, vegetables, and other plant-based foods. Both compounds have been studied extensively for their potential health benefits, including as antioxidants, anti-inflammatories, and neuroprotective agents.

Although fisetin and quercetin share some similarities, they also differ in their mechanisms of action and potential uses. Understanding these differences can help individuals make informed decisions about which compound may be best suited for their individual needs.

Key Takeaways

  • Fisetin and quercetin are flavonoids found in various plant-based foods.
  • Both compounds offer potential anti-aging and other health benefits.
  • Further research is needed to fully understand the mechanisms and optimize the use of these compounds.
  • Consulting with a healthcare professional is recommended for personalized advice on incorporating fisetin or quercetin into one’s wellness routine.

Fisetin Vs Quercetin: Understanding Their Differences

Fisetin and quercetin are both flavonoids, a type of plant pigment. Flavonoids are known for their antioxidant properties and ability to scavenge free radicals that can damage cells and contribute to aging and disease.

Fisetin can be found in fruits and vegetables such as strawberries, apples, grapes, and onions. Quercetin is found in similar sources, including apples, berries, onions, and citrus fruits. Both compounds are also available in supplement form.

The chemical structure of fisetin and quercetin is similar, with a flavone backbone and hydroxyl groups. Fisetin has additional hydroxyl groups, making it more potent as an antioxidant. However, quercetin has a greater bioavailability, meaning it is more easily absorbed and utilized by the body.

When comparing fisetin vs quercetin, it’s important to note that both compounds have unique advantages and uses. Choosing between them may depend on individual needs and preferences.

Antioxidant PotencyMore potent due to additional hydroxyl groupsLess potent but greater bioavailability
SourcesStrawberries, apples, grapes, onionsApples, berries, onions, citrus fruits
Potential UsesSenolytic, anti-inflammatory, brain-boostingAntioxidant, neuroprotectivecardioprotective
Beneficial EffectsCognitive enhancement, cellular senescence reduction, anti-cancerInflammation reduction, allergy relief, skin health improvement

The comparison table shows that fisetin is more potent as an antioxidant and has potential as a senolytic and anti-inflammatory. On the other hand, quercetin has greater bioavailability and is known for its neuroprotective and cardioprotective effects.

Understanding the properties and differences between fisetin and quercetin is essential for maximizing their health benefits. In the next section, we will explore the anti-aging and health benefits offered by these two compounds in greater detail.

quercetin supplement

Anti-Aging and Health Benefits

Both fisetin and quercetin have shown promising anti-aging effects thanks to their senolytic properties. Senolytics are compounds that selectively induce the death of senescent cells, which are responsible for chronic inflammation and contribute to age-related diseases.

Studies have demonstrated that fisetin and quercetin can effectively target and eliminate senescent cells, improving overall health and longevity1. In addition to their senolytic properties, both compounds act as antioxidants, protecting the body from oxidative stress and reducing inflammation.

The neuroprotective effects of fisetin and quercetin are also noteworthy. Fisetin has been shown to improve cognitive function and enhance neurotrophic factors, while quercetin exhibits potent anti-inflammatory and antioxidant activities, which can prevent neuronal damage and preserve brain function.

Moreover, fisetin and quercetin have demonstrated various benefits on skin health. Both compounds have been reported to protect the skin from UV-induced damage, reduce hyperpigmentation, and improve skin texture and structure.

Senolytic EffectsActs as a senolytic agent, targeting and potentially eliminating senescent cells.Acts as a senolytic agent, selectively eliminating senescent cells, contributing to various age-related diseases and tissue dysfunction.
Lifespan ExtensionMay contribute to lifespan extension by alleviating the burden of cell senescence.Shown to extend lifespan in animal studies by reducing senescent cells in tissues and potentially restoring tissue homeostasis.
NeuroprotectionHas neuroprotective effects that could be beneficial against aging-related neurodegenerative diseases.Has neuroprotective effects in animal models of aging-associated neurological disorders, potentially preventing cognitive and memory impairments.
Anti-inflammatory and Antioxidant PropertiesExhibits anti-inflammatory and antioxidant properties that combat chronic inflammation and oxidative stress.Reduces oxidative stress and inflammation, mitigating conditions such as neuroinflammation and brain health issues that worsen with age.
Potential Reduction of Age-Related DiseasesMay play a role in reducing the risk or severity of age-related diseases like chronic inflammation, oxidative stress, and cellular senescence-related issues.Might help reduce the risk of several common age-related diseases, including cancer, diabetes, cardiovascular diseases, and dementia.

Both fisetin and quercetin have various health benefits and have been reported to prevent and improve symptoms of several diseases. Fisetin exhibits anti-inflammatory and anti-cancer properties, while quercetin has been shown to reduce the risk of cardiovascular diseases, prevent cancer cell proliferation, and delay the onset of Alzheimer’s disease.

Incorporating these compounds into one’s diet or taking supplements may provide numerous health advantages, particularly regarding anti-aging, neuroprotection, and disease prevention. However, you must consult a healthcare professional before significantly changing your wellness routine.


After analyzing the properties of fisetin and quercetin, it is clear that both compounds offer numerous health benefits, including anti-aging, neuroprotection, and disease prevention. However, choosing between these two compounds may depend on individual needs and preferences.

While fisetin is a potent senolytic, quercetin has been reported to have anti-inflammatory and cardioprotective effects. Additionally, quercetin is more abundant in dietary sources like apples, onions, and berries, whereas fisetin is present in fewer plant-based sources and may require supplementation.

It is important to note that further research is needed to fully understand these compounds’ mechanisms of action and optimize their use. Consulting with a healthcare professional is recommended for personalized advice on incorporating fisetin or quercetin into one’s wellness routine.


Are Fisetin and Quercetin the same?

No, Fisetin and Quercetin are different antioxidants with distinct chemical structures and sources. They also offer different potential health benefits​​.

How do fisetin and quercetin contribute to anti-aging?

Both fisetin and quercetin possess antioxidant properties, which help reduce oxidative stress and cellular damage. They also exhibit potential senolytic effects, targeting and eliminating senescent cells associated with aging.

Are there any benefits of fisetin and quercetin for the skin?

Fisetin and quercetin have been studied for their potential benefits on skin health, including protecting against UV-induced damage and promoting collagen synthesis.2,3

What are the Side Effects of Quercetin?

Quercetin is generally safe but may cause nausea, headaches, and stomach aches in doses over 1000 mg. It may also interact with certain medications like antibiotics and blood pressure medicines.

How does fisetin work in the body?

Fisetin works by activating various pathways in the body that are involved in cellular health and function. It has been shown to support mitochondrial health, promote autophagy (cellular recycling), and modulate inflammation and oxidative stress.

What is the most effective senolytic?

Fisetin has been identified as the most potent senolytic compound among a group of flavonoids tested in recent studies4. Compared to other plant compounds, including quercetin, fisetin has shown to be the most effective at removing senescent cells both in cell culture and in mice. This makes it a significant focus in anti-aging research.

Can fisetin and quercetin benefit brain health?

Yes, fisetin and quercetin have neuroprotective properties and may enhance cognitive function. They have been studied for their potential to reduce the risk of neurodegenerative diseases like Alzheimer’s.5


  1. Emerging use of senolytics and senomorphics against aging and chronic diseases ↩︎
  2. Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin ↩︎
  3. Fisetin Regulates Nrf2 Expression and the Inflammation-Related Signaling Pathway to Prevent UVB-Induced Skin Damage in Hairless Mice ↩︎
  4. Fisetin is a senotherapeutic that extends health and lifespan ↩︎
  5. Cholinesterase Inhibitory Potential of Quercetin towards Alzheimer’s Disease – A Promising Natural Molecule or Fashion of the Day? – A Narrowed Review ↩︎

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