Anti-Aging Benefits of PQQ

Pyrroloquinoline Quinone (PQQ) emerges as a compound with a fascinating profile, straddling the line between a vitamin-like substance and a potent enhancer of neurological and cellular functions. The optimal daily dosage is 20 mg in adults, except for pregnant or breastfeeding women, ensuring a balance between efficacy and safety. Initially recognized for its crucial role in bacterial growth, PQQ has since revealed its potential to promote antioxidative actions and neuroprotection in more complex organisms.

Found in various foods, from cocoa powder and human milk to natto and green tea, PQQ is accessible through daily diet and offers an array of benefits. It stands out mainly for its capability to improve cognitive functions by stimulating the production of nerve growth factors and shielding neurons against oxidative damage, thus supporting overall brain health. This intriguing compound not only underscores the complexity of nutrition’s role in health but also highlights the continuous discovery of elements that could contribute to longevity and enhanced quality of life.

Key Takeaways:

  • PQQ is a potent antioxidant that offers numerous anti-aging benefits.
  • It supports mitochondrial function and skin rejuvenation and has powerful antioxidant properties.
  • PQQ promotes cognitive function, has anti-inflammatory effects, and enhances energy production.
  • Supplementing with PQQ can provide concentrated doses of this powerful antioxidant for optimal cellular health.

Anti-Aging Benefits of PQQ

Regarding anti-aging, PQQ offers a range of benefits that can promote overall health and vitality. Let’s explore some key advantages of incorporating PQQ into your wellness routine.

Mitochondrial Support

PQQ plays a crucial role in stimulating mitochondrial biogenesis, creating new mitochondria in our cells. Mitochondria are responsible for producing energy and play a key role in aging. By supporting mitochondrial function, PQQ can help enhance energy production and slow down the aging process.

Skin Rejuvenation

PQQ possesses potent antioxidant properties that effectively neutralize harmful free radicals and reduce oxidative stress. This can help protect the skin from damage caused by environmental factors, such as UV radiation, and promote collagen production for smoother, more youthful-looking skin. PQQ’s rejuvenating effects can help you maintain a radiant and vibrant complexion.

Antioxidant Properties

As an antioxidant, PQQ works by scavenging free radicals and reducing oxidative stress. This can help prevent cellular damage and inflammation, which are linked to the aging process. Additionally, PQQ has been shown to stimulate the production of other antioxidants, such as glutathione, further enhancing its anti-aging effects. By combating oxidative stress, PQQ supports cellular health and promotes longevity.

Benefits of PQQ

Other Health Benefits of PQQ

PQQ, also known as Pyrroloquinoline quinone, offers a range of health benefits beyond its anti-aging properties. Ongoing research has revealed its potential to improve cognitive function, reduce inflammation, and enhance energy production.

Cognitive Function Improvement

PQQ has shown promising results in supporting cognitive function and memory. Studies indicate that it promotes the growth of new brain cells and protects existing neurons, leading to improved focus, attention, and overall cognitive performance1. PQQ may play a vital role in maintaining mental sharpness and preventing age-related cognitive decline by nourishing the brain.

Anti-inflammatory Effects

Persistent inflammation is a common factor in aging and various age-related diseases. PQQ exhibits anti-inflammatory properties that can help mitigate inflammation and its detrimental effects on the body. By reducing inflammation, PQQ has the potential to protect against conditions such as arthritis, cardiovascular diseases, and other age-related inflammatory disorders.

Enhanced Energy Production

PQQ’s role in supporting mitochondrial function notably boosts energy production within the body. Mitochondria are the powerhouses of our cells, responsible for generating energy. PQQ enhances energy levels, stamina, and overall vitality by optimizing mitochondrial function. This increase in energy production can contribute to a greater sense of well-being and improved physical performance.

PQQ research

How Does PQQ Supplement Work for Anti-Aging

Pyrroloquinoline Quinone (PQQ) supplements are thought to aid in anti-aging primarily through their effects on your mitochondria, the energy-producing structures in your cells, and their potent antioxidant properties.

One key way that PQQ is believed to exert its anti-aging effects is by stimulating the production of new mitochondria in aging cells, a process known as mitochondrial biogenesis. This is crucial because, over time, the mitochondria in your cells can become less efficient, leading to decreased energy production and accelerated aging. By promoting the growth of new mitochondria, PQQ enhances your cellular energy and potentially slows down the aging process in your body.

In addition to supporting the health of your mitochondria, PQQ provides significant antioxidant protection. It protects your cells from oxidative damage, a major cause of aging and various chronic diseases. This protection extends to different parts of your body, including your brain, heart, and liver, potentially supporting your cognitive functions, improving your cardiovascular health, and aiding in your fat metabolism.

Dosage and Protocol of PQQ Supplements

When it comes to PQQ supplements, understanding the proper dosage and protocol is essential to ensure their effectiveness in supporting overall well-being. Let’s explore the recommended dosage and the best way to incorporate it into your routine.

PQQ Dosage

The recommended dosage of PQQ supplements can vary depending on age, health condition, and desired benefits. The optimal daily dosage is 20 mg in adults, except for pregnant or breastfeeding women, ensuring a balance between efficacy and safety. However, it’s always wise to consult a healthcare professional to determine the right dosage for your specific needs and goals.


It is generally advised to take PQQ supplements once daily for optimal absorption and utilization. Taking PQQ with a meal can further enhance absorption by facilitating digestion and utilization. By following this protocol, you can ensure that your body receives the maximum benefits from PQQ supplementation.

It’s important to note that individual responses to PQQ may vary, and it may take time to experience the supplement’s full effects. Consistency and adherence to the recommended dosage and protocol are key factors in maximizing the benefits of PQQ supplementation.

Precautions and Side Effects of PQQ Supplements


While PQQ is generally safe for most people when taken at recommended dosages, it is advisable to exercise caution, especially for pregnant or breastfeeding women, individuals with pre-existing medical conditions, or those on medication. It is always recommended to consult with a healthcare professional before starting any new supplement.

PQQ Side Effects

PQQ supplements are generally well-tolerated, with minimal reported side effects. However, when taking higher doses, some individuals may experience mild gastrointestinal discomfort, such as nausea or diarrhea. If any adverse reactions occur, discontinue use and seek medical advice.

History of PQQ

PQQ, short for Pyrroloquinoline quinone, was first discovered in 1979 and has since gained significant attention for its potential health benefits. Extensive research has been conducted to explore its mechanisms and effects, revealing its role in promoting cellular health, anti-aging, and cognitive function improvement.

Studies have shown that PQQ supports mitochondrial function, which is essential for energy production and plays a key role in aging2. Its antioxidant properties help neutralize harmful free radicals, reducing oxidative stress and protecting the skin from damage caused by environmental factors.

Furthermore, PQQ exhibits anti-inflammatory effects, helping to reduce inflammation and combat age-related conditions such as arthritis and cardiovascular diseases. It has also been found to enhance cognitive function and memory by promoting the growth of new brain cells and protecting existing neurons.

Research continues to deepen our understanding of PQQ and its applications in promoting overall well-being. As more studies are conducted, we gain valuable insights into its potential benefits and role in supporting a healthy and vibrant life.

history of PQQ


In conclusion, thanks to its profound antioxidative actions and neuroprotective benefits, Pyrroloquinoline Quinone (PQQ) emerges as a powerful ally in the quest for anti-aging and enhanced cognitive functions. As a supplement, it offers a concentrated dose that can significantly bolster mitochondrial health, protect against oxidative damage, and support overall cellular health. Whether through dietary sources or supplementation, incorporating PQQ into your wellness routine could promote longevity and improve the quality of life by slowing down the aging process and enhancing cognitive performance.

It’s essential to adhere to the recommended daily dosage of 20 mg for adults, excluding pregnant or breastfeeding women, to balance efficacy and safety. Always consult with a healthcare professional before beginning any new supplement regimen, especially if you have pre-existing conditions or are on medication. While PQQ is generally well-tolerated, paying attention to your body’s response and adjusting accordingly is key. Ultimately, PQQ supplementation could be a valuable addition to your wellness journey, contributing to a healthier, more vibrant life.


What are the anti-aging benefits of PQQ?

PQQ offers numerous anti-aging benefits, including mitochondrial support, skin rejuvenation, and antioxidant properties. It also improves cognitive function, reduces inflammation, and enhances energy production.

How does PQQ support mitochondria?

PQQ stimulates mitochondrial biogenesis, creating new mitochondria in our cells. PQQ enhances energy production by supporting mitochondrial function and slows down aging.

Can PQQ help rejuvenate the skin?

Yes, PQQ’s antioxidant properties neutralize free radicals and reduce oxidative stress, protecting the skin from environmental damage and promoting collagen production for a more youthful appearance.

What are the other health benefits of PQQ?

In addition to the anti-aging effects, PQQ also improves cognitive function, has anti-inflammatory effects, and boosts energy production in the body.

How does PQQ supplementation work?

PQQ supplements provide a concentrated dose of this antioxidant, which supports mitochondrial function, reduces oxidative stress, and promotes the production of other antioxidants to combat the effects of aging.


  1. Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study ↩︎
  2. Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats ↩︎