Calcium Alpha-Ketoglutarate (CA-AKG) is a specialized anti-aging molecule formulated to maintain normal blood calcium levels by counteracting excess phosphate.  Recommended at 1000mg daily, CA-AKG plays a crucial role in balancing calcium and phosphate, essential for the body’s metabolic functions such as cellular homeostasis, protein synthesis, and fat metabolism.

Moreover, CA-AKG converts to glutamine, detoxifying ammonia and other harmful byproducts, supporting gut health, and aiding in weight management. It also helps synthesize collagen and the proliferation of stem cells. Among various AKG supplements, CA-AKG stands out for its enhanced bioavailability and efficacy, significantly improving longevity and promoting cellular health.

Key Takeaways:

• CA-AKG, or Calcium Alpha-Ketoglutarate, is a compound that offers a range of anti-aging benefits.
• CA-AKG has the potential to promote longevity, reduce age-related inflammation, and enhance cellular metabolism.
• CA-AKG supplements may improve gut health, support bone and muscle health, enhance insulin sensitivity, and benefit cardiovascular and immune function.
• CA-AKG provides the body with additional alpha-ketoglutarate, boosting cellular energy and supporting mitochondrial function.

Anti-Aging Benefits of CA-AKG

CA-AKG, or Calcium Alpha-Ketoglutarate, plays a crucial role in the Krebs cycle, a key metabolic pathway responsible for energy production. This compound offers a range of anti-aging benefits that contribute to improved health and longevity, such as promoting longevity, reducing age-related inflammation, and enhancing cellular metabolism. Notably, AKG levels decrease with age, with levels at age 80 only 10% of what they were at age 40. Therefore, CA-AKG supplements have the potential to slow down the aging process and support overall well-being by helping restore calcium levels in the blood.

After discovering that CA-AKG supplementation consistently decreased epigenetic age in a small homogenous population, we extended our research to a larger cohort. Initially, this entire cohort of 42 patients was, on average, 0.35 years biologically younger than their chronological age. By the end of the treatment, they were, on average, 8.31 years biologically younger than their chronological ages, illustrating the profound impact of CA-AKG supplementation on aging.¹

Promotes Longevity

CA-AKG has been shown to improve cellular health and function, acting as a powerful antioxidant that protects cells from oxidative damage. Studies have demonstrated that CA-AKG supplementation can increase the lifespan of specific organisms, suggesting its potential for extending human lifespan as well². CA-AKG helps slow aging and enhance longevity by supporting cells’ health and resilience.

Reduces Age-related Inflammation

Inflammation is a common feature of aging and is associated with various age-related diseases. CA-AKG possesses anti-inflammatory properties that can help reduce age-related inflammation and its adverse effects on the body. By modulating the immune response and regulating inflammatory molecules, CA-AKG supplementation may contribute to healthier aging and the prevention of chronic inflammation-related conditions.³

Promotion of Cellular Metabolism

Cellular metabolism plays a crucial role in overall health and aging. CA-AKG has been shown to enhance cellular metabolism by supporting the production of ATP, the body’s primary energy source. By improving mitochondrial function and increasing energy production, CA-AKG supplementation may boost physical and mental performance, slow aging, and support overall health and vitality.

Supporting Stem Cell Growth

Stem cells can differentiate into various cell types and play a vital role in tissue regeneration and repair. CA-AKG has been shown to support stem cell growth and enhance their regenerative properties, further contributing to tissue rejuvenation.

Collagen Synthesis

Collagen is a critical protein that provides structure and strength to various tissues, including the skin, cartilage, and tendons. CA-AKG helps to stimulate collagen synthesis, promoting skin elasticity and joint health.

Epigenetic Regulation

Epigenetic regulation refers to the modifications occurring in gene expression without altering the DNA sequence. CA-AKG has been shown to influence gene expression through epigenetic mechanisms, potentially impacting various biological processes and contributing to overall health and longevity.

Other Health Benefits of CA-AKG

Aside from its anti-aging properties, CA-AKG offers a range of other health benefits that can contribute to overall well-being and vitality.

Gastrointestinal Health

CA-AKG has been found to promote gastrointestinal health by maintaining the integrity of the gut lining, reducing inflammation, and improving nutrient absorption. These effects can contribute to better digestive health and reduce the risk of gastrointestinal disorders.

Bone and Muscle Health

CA-AKG plays a crucial role in supporting bone and muscle health. It enhances collagen synthesis, essential for maintaining the strength and structure of bones and connective tissues. Additionally, CA-AKG aids in muscle recovery and growth, benefiting athletes and individuals seeking to improve their physical performance.

Improvement in Insulin Sensitivity

Insulin sensitivity is vital for maintaining healthy blood sugar levels and preventing the development of insulin resistance and type 2 diabetes. CA-AKG has been shown to improve insulin sensitivity, potentially reducing the risk of metabolic disorders and promoting overall metabolic health.

Cardiovascular Health

CA-AKG supplementation may provide cardiovascular benefits by supporting healthy blood pressure levels, improving blood flow, and reducing oxidative stress and inflammation. These effects can support heart health and reduce the risk of cardiovascular diseases.

Immune Function

CA-AKG has been found to have immunomodulatory effects, meaning it helps regulate immune responses and boost immune function. By enhancing the activity of immune cells and promoting a balanced immune system, CA-AKG supplementation may improve overall immune function and reduce the risk of infections and autoimmune conditions.

Supporting Cellular Energy Production

One of the key benefits of CA-AKG supplementation is its ability to support cellular energy production. By optimizing the function of mitochondria, the powerhouse of our cells, CA-AKG helps enhance overall energy levels and vitality. This profoundly impacts various aspects of our health and well-being.

Promoting Physical Performance

When it comes to physical performance, CA-AKG can be a game-changing cellular energy product. It enhances endurance, stamina, and overall athletic performance. Whether you are an avid athlete or simply looking to stay active, CA-AKG can support your physical endeavors and help you push your limits.

Metabolism and Amino Acid Synthesis

CA-AKG also plays a crucial role in metabolism and amino acid synthesis. Supporting the efficient breakdown and utilization of nutrients helps optimize metabolic processes, ensuring that our bodies can effectively convert food into energy. Additionally, CA-AKG aids in synthesizing important amino acids, the building blocks of proteins essential for various physiological functions.

Supporting Muscle Recovery Post-Exercise

After an intense workout, proper muscle recovery is vital for growth and injury prevention. CA-AKG helps to accelerate muscle recovery by reducing oxidative stress and inflammation, supporting the repair and regeneration of muscle tissue. This can help you bounce back faster and continue challenging yourself in your fitness journey.

How Does CA-AKG Supplement Work for Anti-Aging

Dosage and Protocol of CA-AKG Supplements

CA-AKG Dosage

1. For Weight Management and Longevity: The recommended dosage is 1,000mg daily. Expressly, 1,000mg daily, taken in the morning with or without food, is advised​​for longevity.
2. General Use and Effectiveness: A dose of 500mg daily effectively reduces epigenetic age. Ca-AKG is safe in larger doses, and while some individuals take up to 1 or 2 grams per day, there’s no established evidence that higher doses provide increased benefits.
3. Usage Recommendations: It’s best taken with food or without food. It’s crucial to consult a healthcare professional when starting any new supplement, especially if you have preexisting medical conditions or are taking other medications.
4. Maximum Recommended Safe Daily Dose: Up to 6 grams per day. This dosage is considered safe and has been utilized concerning aging and health improvement​​.

CA-AKG supplements can be taken with or without food, depending on personal preference. It is generally recommended to start with a lower dosage and gradually increase it if needed. As with any dietary supplement, it is advisable to consult a healthcare professional before beginning CA-AKG supplementation, especially if you have any underlying medical conditions or are taking medications.

Protocol

When incorporating CA-AKG supplements into your routine, it is essential to establish a protocol for consistent and effective use. Consider the following guidelines:

1. Read and understand the instructions provided by the manufacturer.
2. Consult a healthcare professional to determine the appropriate dosage and frequency for your needs.
3. Start with a lower dosage and gradually increase it if needed while monitoring your body’s response.
4. Take CA-AKG supplements consistently and regularly to maintain steady levels in the body.
5. Keep track of any changes or improvements in your health and well-being to assess the efficacy of CA-AKG supplementation.

By following proper dosage and protocol, you can optimize the benefits of CA-AKG supplements and support your overall health and longevity.

Precautions and Side Effects of CA-AKG Supplements

While CA-AKG supplements are generally safe for consumption, certain precautions should be taken. Before starting any new supplement regimen, especially if you have underlying health conditions or are taking medication, it is advisable to consult with a healthcare professional. They can assess your individual needs and provide personalized guidance.

As with any supplement, side effects are possible, although they are generally rare. It is essential to be aware of these potential side effects and discontinue use if any adverse reactions occur. Some potential side effects of CA-AKG supplements may include:

1. Gastrointestinal discomfort: Some individuals may experience digestive issues such as upset stomach, diarrhea, or bloating. If you experience persistent or severe gastrointestinal discomfort, discontinue use and consult with a healthcare professional.
2.  Allergic reactions: In rare cases, allergic reactions to CA-AKG supplements may occur. These reactions can manifest as skin rashes, itching, swelling, or difficulty breathing. If you develop any signs of an allergic reaction, seek immediate medical attention.
3.  Interactions with certain medications: CA-AKG supplements may interact with certain medications, such as blood thinners or anticoagulants. To avoid potential interactions, you must inform your healthcare professional about all your medicines.

To minimize the risk of side effects and ensure the safe use of CA-AKG supplements, follow the recommended dosage and consult a healthcare professional if you have any concerns or questions.

History of CA-AKG

CA-AKG, also known as Calcium Alpha-Ketoglutarate, has a rich history rooted in biochemistry. It was first discovered and extensively studied for its biochemical properties before its potential health benefits came to light.

Ongoing research has shed light on CA-AKG’s anti-aging effects, leading to its recognition as a valuable supplement for promoting overall health and longevity. The compound’s ability to enhance cellular health and function has generated significant interest among scientists and health enthusiasts.

As research progresses, more mechanisms and potential applications of CA-AKG in various aspects of health and aging continue to be uncovered. Scientists are delving deeper into understanding the compound’s effects on the body, paving the way for further advancements and discoveries.

Conclusion

Calcium Alpha-Ketoglutarate (CA-AKG) is a multifaceted compound with extensive anti-aging and health benefits. From enhancing longevity and cellular metabolism to supporting bone, muscle, and cardiovascular health, CA-AKG stands out as a valuable addition to health regimens and could potentially reverse biological aging.

By supplying the body with additional alpha-ketoglutarate, CA-AKG supports mitochondrial function and energy production, critical factors in slowing the aging process and promoting overall well-being. This aspect is particularly important as it highlights the compound’s role in maintaining energy levels and reducing the effects of aging at the cellular level.

The recommended dosage for CA-AKG varies depending on the desired health outcomes, with 1,000mg daily being a standard recommendation for weight management and longevity benefits. While CA-AKG is generally safe, it’s crucial to consult a healthcare professional before beginning supplementation, particularly if you have preexisting conditions or are taking other medications.

Monitoring for any potential side effects and adjusting the dosage as necessary can help maximize the benefits of CA-AKG while minimizing risks. Adherence to these guidelines, combined with understanding the benefits CA-AKG offers, enables individuals to effectively incorporate this supplement into their health and wellness regimen, supporting their anti-aging efforts and enhancing their quality of life.

FAQ

What are the benefits of CA-AKG supplements?

CA-AKG supplements offer a range of benefits, including promoting longevity, reducing age-related inflammation, supporting cellular metabolism, improving gastrointestinal health, enhancing bone and muscle health, improving insulin sensitivity, supporting cardiovascular health, boosting immune function, and potentially promoting mental health. And it has the potential to reverse biological aging.

Are there any side effects or precautions associated with CA-AKG supplements?

CA-AKG supplements are generally considered safe for most individuals. However, pregnant and breastfeeding women, individuals with specific medical conditions, or those taking certain medications should consult with a healthcare professional before using them. Mild gastrointestinal symptoms such as nausea, bloating, or diarrhea may sometimes occur, but these side effects are generally well-tolerated. If any adverse effects are experienced, it is advisable to discontinue use and consult with a healthcare professional.

How does CA-AKG supplementation work for anti-aging?

CA-AKG provides the body with additional alpha-ketoglutarate, which plays a role in energy production and cellular metabolism. By boosting cellular energy and supporting mitochondrial function, CA-AKG supplementation may counteract the age-related decline in energy production and cellular health. Its antioxidant and anti-inflammatory properties further contribute to its anti-aging effects.

Citations

1. Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test  ↩︎
2. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice ↩︎
3. Reversal of epigenetic aging and immunosenescent trends in humans ↩︎