Alpha-Lipoic Acid Side Effects on Thyroid Health

alpha-lipoic acid side effects thyroid

Alpha-lipoic acid (ALA) is renowned for its powerful antioxidant capabilities, offering a range of health benefits that extend to supporting thyroid health. Particularly beneficial for individuals with thyroid conditions like hypothyroidism and Hashimoto’s Thyroiditis, ALA contributes positively by reducing inflammation, one of the critical factors affecting thyroid function. Additionally, its role in aiding weight loss is notable, as it can indirectly improve thyroid health by addressing obesity-related complications. Research suggests that while ALA may influence the conversion of thyroid hormones, mainly when used alongside thyroid medications such as levothyroxine, the overall impact of its antioxidant potential is often considered to outweigh these concerns1.

For thyroid patients, the judicious use of ALA, under medical guidance, can be a valuable addition to their health regimen, especially given its broad spectrum of benefits that extend beyond thyroid health. However, as with any supplement, individual responses may vary, highlighting the importance of personalized healthcare advice.

Key Takeaways:

  • Alpha-lipoic acid is a powerful antioxidant that has potential health benefits.
  • High doses of alpha-lipoic acid may interfere with thyroid hormone production and function.
  • Monitoring thyroid function is important when taking alpha-lipoic acid supplements, especially with pre-existing thyroid conditions.
  • Consulting with a healthcare professional before starting any new supplements, particularly if you have thyroid issues, is recommended.
  • Proper moderation and dosage are crucial to minimize the risk of side effects on thyroid health.

Alpha-Lipoic Acid Side Effects on Thyroid Health: Is It Safe to Use?

When it comes to alpha-lipoic acid and thyroid health, it’s important to understand the potential side effects that this powerful antioxidant may have on the thyroid. In particular, the impact on thyroid hormone levels is of concern.

Effect on Thyroid Hormone Conversion: A notable study from 1991 showed that alpha-lipoic acid can affect the conversion of T4 (thyroxine) to T3 (triiodothyronine), particularly when taken with levothyroxine, a common thyroid medication2. In this study, alpha-lipoic acid with levothyroxine resulted in a 56% suppression of T4 to T3 conversion over nine days. Therefore, it is advised that individuals taking thyroid hormone medication should consider taking alpha-lipoic acid at a different time, preferably four hours apart from their medication​​.

Antioxidant and Anti-Inflammatory Effects: Alpha-lipoic acid is well-recognized for its antioxidant and anti-inflammatory properties. These properties can benefit thyroid health, especially in conditions like Hashimoto’s Thyroiditis and thyroid eye disease. For instance, alpha-lipoic acid has shown the potential to improve endothelial function and reduce inflammation, essential in thyroid health management​​.

Weight Loss and Thyroid Function: Using alpha-lipoic acid for weight loss can positively affect thyroid function. Obesity and weight gain can adversely affect thyroid function, so aiding weight loss with alpha-lipoic acid can, in turn, improve thyroid health​​.

Inflammation and Thyroid Conversion: Reducing inflammation with alpha-lipoic acid can positively impact T4 to T3 conversion in cases of hypothyroidism and Hashimoto’s. Since widespread inflammation in the body can hinder thyroid hormone conversion, using anti-inflammatory agents like alpha-lipoic acid might be beneficial​​.

Protection Against Thyroid Gland Inflammation: Alpha-lipoic acid may help reduce thyroid gland inflammation, particularly relevant in autoimmune thyroid conditions like Hashimoto’s Thyroiditis. This reduction in inflammation can be positive for overall thyroid function.​

alpha-lipoic acid and thyroid hormone levels

Alpha-Lipoic Acid in Patients with Thyroid Disorders

Individuals with thyroid disorders may be particularly interested in exploring the potential benefits of alpha-lipoic acid. While the research is still emerging, there is growing evidence to suggest that this antioxidant may be beneficial in managing thyroid conditions.

Alpha-lipoic acid has shown potential in improving thyroid function and reducing thyroid antibodies, which could benefit individuals with autoimmune thyroid disorders such as Hashimoto’s thyroiditis. By modulating the immune system and reducing inflammation, alpha-lipoic acid may help alleviate symptoms and support thyroid health.

It’s worth noting that the use of alpha-lipoic acid as a therapy for thyroid disorders should be approached with caution and under the guidance of a healthcare professional. Treatment plans for thyroid disorders are highly individualized, and it’s essential to work closely with a healthcare provider to determine the best approach for managing your specific condition.

Considering Dosage: How Much is Too Much?

Determining the appropriate dosage is crucial when considering alpha-lipoic acid for thyroid health. Starting with a low dose and gradually increasing it under the guidance of a healthcare professional is recommended to minimize the risk of potential side effects.

While there is no standard dosage for alpha-lipoic acid, typical recommendations range from 300 to 600 mg daily. However, it’s essential to remember that individual requirements and tolerances may vary, and only a healthcare professional can provide personalized dosage recommendations based on your specific needs and health status.

It’s worth noting that higher doses of alpha-lipoic acid may increase the risk of side effects, including those on thyroid health. Therefore, it’s essential to follow the guidance of a healthcare professional and avoid exceeding the recommended dosage.

alpha-lipoic acid side effects thyroid


In conclusion, alpha-lipoic acid (ALA) shows promise as a beneficial supplement for individuals with thyroid disorders, particularly due to its antioxidant and anti-inflammatory properties. These qualities can positively impact thyroid health, especially in conditions like Hashimoto’s Thyroiditis and hypothyroidism. ALA’s potential to aid in weight loss and improve endothelial function further supports its role in managing thyroid health.

However, it is crucial to approach the use of ALA with caution, particularly in those taking thyroid hormone medications like levothyroxine, due to its impact on thyroid hormone conversion. Monitoring thyroid function is essential when using ALA supplements, and any supplementation should ideally be spaced apart from thyroid medications.

The dosage of ALA is a critical factor; starting with a low dose and adjusting it under medical supervision can minimize the risk of side effects. While typical dosages range from 300 to 600 mg daily, this can vary based on individual health needs and conditions.

Ultimately, while ALA can be a valuable addition to a thyroid health regimen, its use should be personalized and closely monitored by healthcare professionals. This ensures that the benefits of ALA are maximized while minimizing potential risks, especially in individuals with existing thyroid conditions.


  1. Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine. ↩︎
  2. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. ↩︎

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